Cochrane Summary of Findings: Horse Chestnut Seed Extract for Chronic Venous Insufficiency

Horse chestnut – efficacy and safety in chronic venous insufficiency: an overview

The extract from horse chestnut seeds (Aesculus hippocastanum L., Sapindaceae), standardised for the content of aescin, is used as the treatment for chronic venous insufficiency. It has anti-inflammatory and anti-oedematous properties and indicates a positive effect on the venous tone, rheological properties, and blood coagulability. The mechanism of horse chestnut seed extract/aescin activity ...

Treatment of patients with venous insufficiency with fresh plant horse chestnut seed extract: a review of 5 clinical studies.

Extracts from the seed of the horse chestnut (Aesculus hippocastanum L.) have traditionally been used to treat patients with chronic venous insufficiency and to alleviate its associated symptoms, including lower leg swelling. The efficacy of preparations that contain horse chestnut seed extract (HCSE) is believed to be due largely to an inhibitory effect on the catalytic breakdown of capillary ...

Review: horse chestnut seed extract is effective for symptoms of chronic venous insufficiency.

Horse-chestnut (Aesculus hippocastanum) seed extract for venous leg ulceration: a comparative multiple case study of healers and non-healers

Background Venous leg ulceration (VLU) is a chronic and recurrent condition that affects around 0.12–1.1% of the Western population. One intervention that is showing promise as a treatment for VLU is horse-chestnut (Aesculus hippocastanum) seed extract (HCSE), with evidence suggesting that HCSE treatment may reduce wound slough, the frequency of dressing changes and the overall cost of VLU mana...

Horse Chestnut - Aesculus Hippocastanum: Potential Applications in Cosmetic Skin-care Products.

In addition to the well reported beneficial effects of horse chestnut (Aesculus hippocastanum) extracts on venous insufficiency and associated conditions, such preparations also have many potential positive pharmacological effects on the skin. Extracts from this species, and in particular, those based on horse chestnut seeds, contain saponins, known collectively as 'aescin', which have a gentle...